Now it is time to speak about Bristol-Myers Squibb (BMS) in our chronological history of pharmaceutical companies.  When we think of BMS, some remarkable achievements immediately come to mind:  Paclitaxel (Taxol®): isolated in the early 1970s, became a blockbuster cancer therapy) that changed oncology  Mass production of penicillin during WWII, which saved countless lives  Opdivo®, a breakthrough immunotherapy first approved for melanoma, which reshaped cancer treatment and later expanded to many other cancers  And the…

The journey of ASPIRIN The journey of aspirin spans millennia—from ancient herbal remedies to an industrial pharmaceutical icon.  Between 3000 and 1500 BC, Sumerians and Egyptians used willow bark to treat pain and inflammation. The Ebers Papyrus confirms its use as a natural analgesic. Around 400 BC, Hippocrates administered willow leaf tea to ease childbirth.  In 1763, Oxfordshire vicar Edward Stone documented willow bark’s fever-fighting effects to the Royal Society. By 1828, Joseph Buchner isolated…

GSK legacy shaped by Beecham’s Pills and Research Laboratories GSK’s earliest roots include Plough Court Pharmacy, founded in London in 1715 by Silvanus Bevan, which later evolved into Allen & Hanburys, well known for its pioneering work in respiratory medicines. However, thanks to Beecham’s Pills, launched in 1842 by Thomas Beecham (1820–1907), the company experienced a tremendous financial boost that drove its early success and enabled its growth into a primary pharmaceutical business. These popular over-the-counter…

From Apothecary to Alkaloid Pioneer: The Origins of Merck and Modern Drug Discovery Did you know that Merck, one of the oldest pharmaceutical companies in the world, played a foundational role in the development of alkaloid chemistry, laying the groundwork for modern medicinal chemistry and compound screening?  The story begins in 1668, when Friedrich Jacob Merck purchased the Engel-Apotheke (Angel Pharmacy) in Darmstadt, Germany. However, the real transformation occurred in 1827, when Heinrich Emanuel Merck…

Toxicology and Preclinical Testing (Animal Models) Today, I would like to share with you the story of another individual who made a remarkable contribution to the history of drug development. The person who laid the basis for modern preclinical animal model tox evaluations was Johann Wepfer (1620–1695).  A Swiss Pioneer of Toxicology and Preclinical Testing (Animal Models).  Long before modern drug development, Wepfer made groundbreaking strides in toxicological analysis. He is best known for his…

Dose Makes The Poison Today I’d like to tell you about a Swiss gentleman named Paracelsus.  Often called the “father” of modern toxicology and pharmacology, Paracelsus was the first to articulate a principle that still underpins toxicology today: “The dose makes the poison.” He argued that no substance is inherently toxic; it all depends on how much of it you take. Even substances we consider harmful can be beneficial in tiny amounts. Paracelsus famously used…