Molport Blog
In News

Molport Chronicles- from Alchemy to Pharma No.6

2 Mins Read

The journey of ASPIRIN The journey of aspirin spans millennia—from ancient herbal remedies to an industrial pharmaceutical icon.  Between 3000 and 1500 BC, Sumerians and Egyptians used willow bark to treat pain and inflammation. The Ebers Papyrus confirms its use as a natural analgesic. Around 400 BC, Hippocrates administered willow leaf tea to ease childbirth.  In 1763, Oxfordshire vicar Edward Stone documented willow bark’s fever-fighting effects to the Royal Society. By 1828, Joseph Buchner isolated…

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In News

Science Picks by Molport- September 2025

7 Mins Read

September 29th Discovery of ZN-c5, an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) with Improved Pharmacokinetics https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5c00887 Abstract Here, we report our strategy to design an optimized oral selective estrogen receptor degrader (SERD), including human pharmacokinetics, by exploiting the bicyclo[1.1.1]pentane (BCP) ring system. The BCP has been shown to serve as a surrogate for phenyl rings and alkyl groups in drug candidates, reducing metabolism and improving physicochemical properties. It has not been extensively profiled in…

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In News

Q4 alert: Order your compounds early

2 Mins Read

Given the increased volume of orders in Q4, along with busy suppliers and couriers, we highly recommend placing your orders well in advance to ensure timely delivery and avoid any unexpected delays, such as those that may occur in the purchasing department. Please, include enough time to build and optimize the list of compounds to be ordered, negotiate favorable terms with suppliers, and do the paperwork required by your organization internally. To provide you with…

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In News

Molport Chronicles- from Alchemy to Pharma No.5

2 Mins Read

GSK legacy shaped by Beecham’s Pills and Research Laboratories GSK’s earliest roots include Plough Court Pharmacy, founded in London in 1715 by Silvanus Bevan, which later evolved into Allen & Hanburys, well known for its pioneering work in respiratory medicines. However, thanks to Beecham’s Pills, launched in 1842 by Thomas Beecham (1820–1907), the company experienced a tremendous financial boost that drove its early success and enabled its growth into a primary pharmaceutical business. These popular over-the-counter…

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In Search & Order

Find Related Compounds Faster with Molport Similarity Search

1 Min Read

Looking for molecules similar to the one you already know? Our Molport Similarity Search tool makes it simple to explore related compounds and expand your options. Begin by identifying your molecule using SMILES, CAS Number, Molport ID, or other unique identifiers. From the molecule’s page, just one click launches a search for similar structures—ready for you to filter, review, and refine. Prefer a hands-on approach? You can also draw your own structure, convert identifiers, set…

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In News

Molport Chronicles- from Alchemy to Pharma No. 4

2 Mins Read

From Apothecary to Alkaloid Pioneer: The Origins of Merck and Modern Drug Discovery Did you know that Merck, one of the oldest pharmaceutical companies in the world, played a foundational role in the development of alkaloid chemistry, laying the groundwork for modern medicinal chemistry and compound screening?  The story begins in 1668, when Friedrich Jacob Merck purchased the Engel-Apotheke (Angel Pharmacy) in Darmstadt, Germany. However, the real transformation occurred in 1827, when Heinrich Emanuel Merck…

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In Search & Order

Discover the Power of Molport List Search Tool

1 Min Read

Need to source multiple compounds quickly and efficiently? The Molport List Search tool allows you to search for up to 10,000 compounds simultaneously, providing instant access to availability, pricing, lead times, and supplier details. With just a free registration, you can upload your list in SD or SMILES format, or paste SMILES/MolPort IDs directly from Excel. In just a few steps, you’ll receive the best offer calculation, download quotes in multiple formats, and even place your order online. Whether…

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In Platform Updates

Science Picks by Molport- August 2025

4 Mins Read

August 25th The Logic of Chemical Optimization https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5c00445 Abstract During multiparameter chemical optimization, molecular capabilities increase as hits evolve into leads and development candidates. Like retrosynthetic analysis, where target molecules are transformed into structurally simplified starting materials, we introduce retro-optimization analysis, transforming sophisticated development candidates into less capable leads and hits. To retrospectively understand the logic of optimization in discovery campaigns, we enumerated a matched molecular pair network and compared the actual route of optimization…

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In Database

Discover the Ways to Access the Molport Database

1 Min Read

Looking to explore Molport’s rich compound data for your research? In this quick tutorial, we walk you through three simple ways to access the Molport Database—whether you prefer a direct download, advanced FTP access, or seamless API integration. Learn which option best fits your needs, how to get started, and where to request access. Watch now to make the most of Molport’s powerful resources. 🎥 Watch the full tutorial here: Molport Database Access Options

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In Platform Updates

Science Picks by Molport- July 2025

4 Mins Read

July 28th Discovery of a New Class of Orexin 2 Receptor Agonists as a Potential Treatment for Narcolepsy https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5c00362 Abstract The orexinergic system, projecting from the lateral hypothalamus, operates through two receptors, orexin receptor type-1 (OX1) and orexin receptor type-2 (OX2), stabilizing wakefulness, mainly via OX2. Narcolepsy Type 1 (NT1) is characterized by excessive sleepiness and cataplexy, and is linked to a loss of orexin-producing neurons. Current therapies manage the symptoms but do not address…

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