March 24, 2020

MolPort is here to help


As MolPort is based in Riga, we’re happy to report that the Latvian authorities took correct, early, proactive measures (before many European and other countries) and the corona virus situation seems to be under control so far – though we are all watching to see how things may develop. 

At MolPort we are working 100% as usual. As well as following all public recommendations, we’re taking special preventative measures for our employees: and we’re monitoring the activities, performance, and individual circumstances at all our suppliers, in order to anticipate any potential changes in your orders. 

We are committed to our employees’ safety and well-being, while at the same time running the business in a responsible manner with all our functions and services working normally. We hope that the circumstances will eventually improve for everybody around the world.

MolPort Services


We understand customers’ requirements to minimize disruption to your research programs, and we are available to offer whatever help you need for regular orders, library design data, consulting, sample sourcing, ordering, reformatting, and logistics. 
We are working as normal with all orders and inquiries.

  • Our Customer Support and Key Account Manager teams are fully available during office hours, as responsive as always.
  • The Laboratory is running ongoing daily reformatting operations.
  • Logistics: MolPort is shipping orders as usual. We are contacting our courier service providers daily, to ensure that we have latest update for all orders. FedEx/TNT/DHL are operating their own airplanes. One possible change in procedures is that we may need to get confirmation from order recipients that they can actually receive the parcel from us.

Using consolidated delivery from MolPort instead of receiving many packages from different suppliers might be of particular value now, as some companies are restricting parcel delivery to a maximum per day.

  • Suppliers
GreenSupplier is working as usual
Light greenSupplier is working, some minor delays are possible
RedSupplier is closed

SupplierColor codeNotes
A2B Chem LLC
AA BLOCKS
ACINTS
Advamacs
AK Scientific, Inc.
AKL Research LLP
Aldlab
Alinda Chemical Trading Company
AnalytiCon Discovery, GmbHSupplier is restructuring their lab due to Coronavirus. There may be slight delay of a few days during this period
Angene
Angene (China)
Apexmol technology Co.,Ltd
Apollo Scientific
Aronis
Axon Medchem
BioBlocks
BIONET - Key Organics Ltd.
BIOTREND Chemicals, AG
BLD Pharmatech Ltd.
Cayman Europe
Certumtech, UAB
Chem4Pharma
ChemBridge Corporation
ChemDiv, Inc.
ChemFaces
Chemscene
Chiralix
Combi-Blocks, Inc.
Debye Scientific
Dr. Silviu Pharmachem
EDASA Scientific
ENAMINE Ltd.
EvoBlocks, Ltd.
Eximed
FCH Group (made-to-order)
Fluorochem Limited
HTS Biochemie Innovationen
InterBioScreen Doo.
IRIS Biotech
Keminntek Laboratories
Labseeker
LeadGen Labs
Life Chemicals Inc.
Manchester Organics
Maybridge, Ltd.
MedChemExpress Europe
MolPort, Ltd.
Otava, Ltd.
PBMR Labs Ukraine (made-to-order)
Pharmeks, Ltd.
Pure Chemistry Scientific
Ramidus AB
Selleck Chemicals LLC
SpecsSmall delays possible for the next few weeks due to government restrictions
SpiroChem
Squarix GmbH
SynChem, Inc.
Synthenova
Synthonix
TargetMol
Tocris Bioscience
UkrOrgSynthesis Ltd. (stock)
Vitas-M Laboratory, Ltd.

If any of our suppliers faces closure, our extensive coverage should allow us to source any needed compounds from many other suppliers.

Frequently asked questions


1. What happens if at some point I can't receive my package?

If the recipient can't temporarily receive parcels, that's OK: the packages won’t get stuck in limbo. MolPort can store your orders free of charge for a few weeks if there are issues when we are ready to ship your compounds, such as your logistics facility being closed. Once we get your green light, we’ll ship safely to the destination.

2. What happens to my order if some compounds are delayed in a multiple-compound order? Can the delivery be split or sent as a partial delivery? Are there additional costs for splitting?

MolPort will be tracking the fulfillment of your order, and we will contact you promptly if any supplier cannot make a shipment in the expected time frame. If any part of the order is delayed, we will offer a split shipment at no additional delivery cost.

3. If a supplier is closed, will I still see their compounds in search results?

Their compounds still will be visible in our searches: but the lead time will be an estimate, based on when we think they will open.

4. What will happen to my order if national borders are closed?

For now they are not closed for logistics, and if a supplier can’t ship, we can substitute the supplier, if possible. If a supplier can ship, but MolPort can’t, we would organize drop-shipping. If a supplier can ship but the client can’t receive the shipment, we can hold it in our warehouse. 

5. How should I purchase compounds, in order to receive them in the fastest possible time?

Check the most recent lead time for the supplier. We will update supplier lead times based on the latest information that we receive from them. And read our Blog update for specific supplier details and information.

6. What will happen to my order if I order from a specific supplier, and they can’t ship?

We can switch the suppliers, if the customer is willing to accept any price differences, and if the compound(s) are actually available at different suppliers.

7. What are MolPort doing to stay open and continue operations?  What precautions are MolPort taking and how?

We are following all government and World Health Organization guidelines. 

!!! Please add your question in the comment area, and we will post the answer in the Blog

February 13, 2020

On Compound Salt Forms

In order to dissolve a compound to make a solution of a specified concentration, you need to know its molecular weight. Most compounds are sold in a pure (non-salt) free form and it is clear what the molecular weight is: but a number of compounds are sold in a salt form, which means that you need to calculate the effective molecular weight that takes into account the compound to salt weight ratio. We therefore strongly prefer the salt information to be included in the structure diagram of the product, as in this example:

tert-butyl 4-(3-aminopyrrolidin-1-yl)piperidine-1-carboxylate

sesquioxalate

tert-butyl 4-(3-aminopyrrolidin-1-yl)piperidine-1-carboxylate has molecular formula C14H27N302 and molecular weight 269.39 g mol-1.

The effective molecular weight can then be normalized to one molecule of the compound and used to calculate the weight of compound needed for a particular concentration. For the example above dot-disconnected is formula C14H27N302.1:1.5C2H2O4 and effective molecular weight 404.44 g mol-1.


Suppliers don’t always include salt data in the chemical structure diagram of the compound. A common approach is to include a field called Salt or Salt Data where the salt identity and stoichiometric ratio can be provided.

There are over 1600 unique salt comments in the MolPort database. This means that a given salt may be described in text in multiple ways.

Here are some examples we see for representing the chloride salt of a compound:

Representing the chloride salt of a compound

When stoichiometry and salt and solvate combinations are included, there are even more variations.



Here are the 100 most commonly encountered salt field comments:



While it is feasible to manually calculate the correct effective molecular weight for one or a few compounds, it is nevertheless inconvenient. For large library acquisitions, manual interpretation and calculation are simply not practical. At MolPort we have been working on a process that interprets supplier-provided salt data comments and adds this information to the chemical structure of a product.

Currently we are successfully processing approximately 99% of the salt comments. When we update supplier catalogs, this information is transformed and added to the chemical structure. The free form and the salt form are saved as different structures and are assigned different MolPort IDs. As we process more and more supplier catalogs with the new process, you will notice that some of the previously available free-form compounds become unavailable and new MolPort IDs become available (for the salt forms of the structures).

We are planning to add new fields to the MolPort database export files and API. We will post more details in the near future.

Imants Zudāns
CEO
molport.com

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